愛知工業大学

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愛知工業大学
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北出 幸夫 (キタデ ユキオ,KITADE Yukio)

基本情報 研究分野 研究業績 教育業績 運営業績 社会貢献業績

 

書籍等出版物
No.タイトル, 著者, 出版社, 出版年月, ID:ISBN, URL 
1
Synthesis of acetylene- substituted probes with benzene-phosphate backbones for RNA labeling , Kitamura, Y., Ueno, Y., Kitade, Y, Curr. Protoc. Nucleic Acid Chem. Unit 4.59. 57, 1-15 (2014), 2014年06月, ,  
2
Current and future asthma therapies, Kandeel, M., Balaha, M., Inagaki, N., Kitade, Y, Drugs Today (Barc). 2013, 49, pp 325-339., 2013年05月, ,  
3
核酸化学のニュートレンド DNA・RNAの新たな可能性を拓く日本化学会編, 佐々木茂喜、杉本直己、中谷和彦 他31名 分担著者 : 北出 幸夫, 化学同人, 2011年07月, ,  
4
MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug, Kitade, Y., Akao, Y, J, Pharmacol, Sci., 2010, 114, pp 276-280., 2010年10月, ,  

 

論文
No.タイトル, 著者, 誌名, 巻( 号), 開始ページ- 終了ページ, 出版年月, ID:DOI, URL 
1
New solid phase submonomer synthesis of arylopeptoid oligomers using reductive amination, Ikeda Masato, Horio Keito, Tsuzuki Tomoya, Torii Ryo, Shibata Aya, Kitamura Yoshiaki, Katagiri Hiroshi, Kitade Yukio, Tetrahedon LettersVol.56, No.48, p.6726-6729, ,   , 2015年12月, ,  
2
Structural insights into reaction mechanism of S-adenosyl-L-homocysteine hydrolase, Kusakabe Yoshio, Ishihara Masaaki, Umeda Tomonobu, Nakanishi Masayuki, Kitade Yukio, Gouda Hiroaki, Nakamura Kazuo T, Tanaka Nobutada, Scientific Reportsdoi: 10.1038/srep16641, ,   , 2015年12月, ,  
3
Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily, Endo Satoshi, Noda Misato, Ikari Akira, Tatematsu Kenjiro, El-Kabbani Ossama, Hara Akira, Kitade Yukio, Matsunaga Toshiyuki, The Journal of BiochemistryVol.158, No.5, p.425-434, ,   , 2015年05月, ,  
4
Identification of a determinant for strict NADP(H)-specificity and high sensitivity to mixed-type steroid inhibitor of rabbit aldo-keto reductase 1C33 by site-directed mutagenesis, Endo, S., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A., Kitade, Y, Archives of Biochemistry and BiophysicsVol.569, p.19-25, ,   , 2015年, ,  
5
Practical and reliable synthesis of 1,2-dideoxy-D-ribofuranose and its application in RNAi studies, Nagaya Yuki, Kitamura Yoshiaki, Nakashima Remi, Shibata Aya, Ikeda Masato, Kitade Yukio, Nucleosides, Nucleotides and Nucleic AcidsVol.35, No.2, p.64-75, ,   , 2015年, ,  
6
Pro-apoptotic Peptide Amphiphile Self-assembled with the Assistance of Polycations, Ikeda Masato, Kawakami Maika, Kitade Yukio, Chemistry LettersVol.44, No.8, p.1137-1139, ,   , 2015年, ,  
7
Probing AKR1C30 and AKR1C31 with site-directed mutagenesis: identifying the roles of residues 54 and 56 in the binding of substrates and inhibitors, Endo Satoshi, Arai Yuki, Matsunaga Toshiyuki, Ikari Akira, El-Kabbani Ossama, Hara Akira, Kitade Yukio, Biological and Pharmaceutical BulletinVol.37, No.11, p.1848-1852, ,   , 2014年11月, ,  
8
Toyooka, N., Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3, Endo Satoshi, Hu Dawai, Matsunaga Toshiyuki, Otsuji Yoko, El-Kabbani Ossama, Kandeel Mahmoud, Ikari Akira, Hara Akira, Kitade Yukio, Toyooka Naoki, Bioorganic & Medicinal ChemistryVol.22, No.19, p.5220-5233, ,   , 2014年10月, ,  
9
Unit 4.59. Synthesis of acetylene-substituted probes with benzene-phosphate backbones for RNA labeling, Kitamura Yoshiaki, Ueno Yoshihito, Kitade Yukio, Current Protocols in Nucleic Acid ChemistryVol.57, p.1-15, ,   , 2014年06月, ,  
10
Bioenergetics and Gene Silencing Approaches for Unraveling Nucleotide Recognition by the Human EIF2C2/Ago2 PAZ Domain, Kandeel Mahmoud, Al-Taher Abdullah, Nakashima Remi, Sakaguchi Tomoya, Kandeel Ali, Nagaya Yuki, Kitamura Yoshiaki, Kitade Yukio, PLoS ONEVol.9, No.5, e94538, ,   , 2014年05月, ,  
11
PLEKHG2/FLJ00018, a Rho family-specific guanine nucleotide exchange factor, is tyrosine phosphorylated via the EphB2/cSrc signaling pathway, Sato Katsuya, Suzuki Takahiro, Yamaguchi Yoshihiro, Kitade Yukio, Nagase Takahiro, Ueda Hiroshi, Cellular SignallingVol.26, No.4, p.691-696, ,   , 2014年04月, ,  
12
Cu/HP20-Catalyzed Solvent-Free Huisgen Cycloaddition at Ordinary Temperatures, Kitamura Yoshiaki, Taniguchi Kazumi, Maegawa Tomohiro, Monguchi Yasunari, Kitade Yukio, Sajiki Hironao, HeterocyclesVol.88, No.1, p.233-243, ,   , 2014年04月, ,  
13
Threonine 680 Phosphorylation of FLJ00018/PLEKHG2, a Rho Family-specific Guanine Nucleotide Exchange Factor, by Epidermal Growth Factor Receptor Signaling Regulates Cell Morphology of Neuro-2a Cells, Sato Katsuya, Sugiyama Tsuyoshi, Nagase Takahiro, Kitade Yukio, Ueda Hiroshi, Journal of Biological ChemistryVol.289, No.14, p.10045-10056, ,   , 2014年04月, ,  
14
Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds, Endo Satoshi, Matsunaga Toshiyuki, Arai Yuki, Ikari Akira, Tajima Kazuo, El-Kabbani Ossama, Yamano Sigeru, Hara Akira, Kitade Yukio, Drug Metabolism and DispositionVol.42, No.4, p.803-812, ,   , 2014年04月, ,  
15
Molecular dynamics and energetic perceptions of substrate recognition by thymidylate kinase, J , Kandeel Mahmoud, Noguchi Yoshihiro, Oh-Hashi Kentaro, Kim Hye-Sook, Kitade Yukio, Journal of Thermal Analysis and CalorimetryVol.115, No.3, p.2089-2097, ,   , 2014年03月, ,  
16
Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides, Ren Qin, Tsunaba Kana, Kitamura Yoshiaki, Nakashima Remi, Shibad Aya, Ikeda Masato, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.24, No.6, p.1519-1522, ,   , 2014年03月, ,  
17
Association of host tropism of Middle East syndrome coronavirus with the amino acid structure of host cell receptor dipeptidyl peptidase 4, Kandeel Mahmoud, Elaiziz MA., Kandeel A, Altaher AA, Kitade Yukio, Acta ViologicaVol.58, No.4, p.359-363, ,   , 2014年, ,  
18
Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, Endo Satoshi, Matsunaga Toshiyuki, Matsumoto Atsuko, Arai Yuki, Ohno Satoshi, El-Kabbani Ossama, Tajima Kazuo, Bunai Yasuo, Yamano Sigeru, Hara Akira, Kitade Yukio, Bioorganic PharmacologyVol.86, No.9, p.1366-1375, ,   , 2013年11月, ,  
19
Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10, Endo Satoshi, Hu Dawei, Suyama Miho, Matsunaga Toshiyuki, Sugimoto Kenji, Matsuya Yuji, El-Kabbani Ossama, Kuwata Kazuo, Hara Akira, Kitade Yukio, Toyooka Naoki, Bioorganic & Medicinal ChemistryVol.21, No.21, p.6378-6384, ,   , 2013年11月, ,  
20
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase, Endo Satoshi, Arai Yuki, Hara Akira, Kitade Yukio, Bunai Yasuo, El-Kabbani Ossama, Matsunaga Toshiyuki, Biological and Phamaceutical BulletinVol.36, No.9, p.1514-1518, ,   , 2013年09月, ,  
21
Synthesis of carbocyclic pyrimidine nucleosides and their inhibitory activities against Plasmodium falciparum thymidylate kinase, Noguchi Yoshihiro, Yasuda Yuri, Tashiro Makoto, Kataoka Tadashi, Kitamura Yoshiaki, Kandeel Mahmoud, Kitade Yukio, Parasitology InternationalVol.62, No.4, p.368-371, ,   , 2013年08月, ,  
22
Chemically modified siRNAs and miRNAs bearing urea/thiourea-bridged aromatic compounds at their 3'-end for RNAi therapy, Kitamura Yoshiaki, Masegi Yuki, Ogawa Shunsuke, Nakashima Remi, Akao Yukihiro, Ueno Yoshihito, Kitade Yukio, Bioorganic & Medicinal ChemistryVol.21, No.15, p.4494-4501, ,   , 2013年08月, ,  
23
Synthesis of oligonucleotides with glucosamine at the 3'-position and evaluation of their biological activity, Luo Xiong, Sugiura Takahiro, Nakashima Remi, Kitamura Yoshiaki, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.23, No.14, p.4157-4161, ,   , 2013年07月, ,  
24
In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference, Kandeel Mahmoud, Kitade Yukio, Journal of Computer-Aided Molecular DesignVol.27, No.7, p.605-614, ,   , 2013年07月, ,  
25
Chemically Modified Synthetic microRNA-205 Inhibits the Growth of Melanoma Cells In Vitro and In Vivo, Noguchi Shunsuke, Iwasaki Junya, Kumazaki Minami, Mori Takashi, Maruo Kohji, Sakai Hiroki, Yamada Nami, Shimada Kazuyuki, Naoe Tomoki, Kitade Yukio, Akao Yukihiro, Molecular TherapyVol.21, No.6, p.1204-1211, ,   , 2013年06月, ,  
26
Structural Biology for Developing Antimalarial Compounds, Tanaka Nobutada, Umeda Tomonobu, Kusakabe Yoshio, Nakanishi Masayuki, Kitade Yukio, Nakamura Kazuo T, YAKUGAKU ZASSIVol.133, No.5, p.527-537, ,   , 2013年05月, ,  
27
Thermodynamics and molecular bases of the interaction of ampicillin and streptomycin at their binding sites of bovine serum albumin, Kandeel Mahmoud, Nakashima Remi, Kitamura Yoshiaki, Balaha Mohamed, Abdelaziz Magdy, Kitade Yukio, Journal of Thermal Analysis and CalorimetryVol.112, No.2, p.945-952, ,   , 2013年05月, ,  
28
Macromolecular interactions of spectinomycin with Bovine serum albumin, Kandeel Mahmoud, Nabih Mohamed, Kitade Yukio, Journal of Thermal Analysis and CalorimetryVol.111, No.3, p.1737-1741, ,   , 2013年03月, ,  
29
Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing, Kandeel Mahmoud, Kitade Yukio, PLoS OneVol.8, No.2, e57140, ,   , 2013年02月, ,  
30
Solvent-free Huisgen cyclization using heterogeneous copper catalysts supported on chelate resins, Monguchi Yasunari, Nozaki Kei, Maejima Toshihide, Shimoda Yutaka, Sawama Yoshinari, Kitamura Yoshiaki, Kitade Yukio, Sajiki Hironao, Green ChemistryVol.15, No.2, p.490-495, ,   , 2013年01月, ,  
31
Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein, Sato Katsuya, Handa Hiroaki, Kimura Masashi, Okano Yukio, Nagaoka Hitoshi, Nagase Takahiro, Sugiyama Tsuyoshi, Kitade Yukio, Ueda Hiroshi, Cellular SignallingVol.25, No.1, p.41-49, ,   , 2013年01月, ,  
32
Stereoselective synthesis of 1-deoxy-1-ethynyl-beta-D-ribofuranose as a versatile scaffold, Kitamura Yoshiaki, Edayoshi Kana, Kitade Yukio, Tetrahedron LettersVol.53, No.51, p.6987-6989, ,   , 2012年12月, ,  
33
Development of diversified methods for chemical modification of the 5,6-double bond of uracil derivatives depending on active methylene compounds, Sajiki Hironao, Iida Yusuke, Ikawa Kanoko, Sawama Yoshinari, Monguchi Yasunari, Kitade Yukio, Maki Yoshifumi, Inoue Hideo, Hirota Kosaku, Laboratory of Organic ChemistryVol.17, No.6, p.6519-6546, ,   , 2012年12月, ,  
34
The Binding Interactions of the Macrolide Endectocide Ivermectin with the Antibiotics Ampicillin,Chloramphenicol and Tetracycline HCl, Kandeel Mahmoud, Elgazar W, Kitade Yukio, Indian Journal of Pharmaceutical SciencesVol.74, No.6, p.592-596, ,   , 2012年11月, ,  
35
Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK), Kato Aya, Yasuda Yuri, Kitamura Yoshiaki, Kandeel Mahmoud., Kitade Yukio, ParasitologyVol.61, No.3, p.501-503, ,   , 2012年09月, ,  
36
PMA-induced GCMa phosphorylation stimulates its transcriptional activity and degradation, Yasui Yuko, Miyazawa Daisuke, Ueda Hiroshi, Sato Katsuya, Kitade Yukio, Yamada Kazuyo, Biomedical ResearchVol.33, No.4, p.217-224, ,   , 2012年08月, ,  
37
Molecular Characterization and Mutational Analysis of Recombinant Diadenosine 5’,5”-P1,P4-Tetraphosphate Hydrolase from Plasmodium falciparum, Osman Waleed, Endo Satoshi, Oh-hashi Kentaro, Kitamura Yoshiaki, Kitade Yukio, Biological & Phrmaceutical BulletinVol.35, No.7, p.1191-1196, ,   , 2012年07月, ,  
38
Double-stranded oligonucleotides containing 5-aminomethyl-2'-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA, Shibata Aya, Ueno Yoshihito, Iwata Mari, Wakita Haruka, Matsuda Akira, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.22, No.8, p.2681-2683, ,   , 2012年04月, ,  
39
Synthesis and biological properties of chemically modified siRNAs bearing 1-deoxy-D-ribofuranose in their 3'-overhang region, Bioorg, Taniho Kazumi, Nakashima Remi, Kandeel Mahmoud, Kitamura Yoshiaki, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.22, No.7, p.2518-2521, ,   , 2012年04月, ,  
40
PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway, Yasui Yuko, Yamada Kazuyo, Takahashi Satoru, Sugiura-Ogasawara Mayumi, Sato Katsuya, Miyazawa Daisuke, Sugiyama Tsuyoshi, Kitade Yukio, Ueda Hiroshi, Biochemical and Biophysical Research CommunicationsVol.417, No.4, p.1127-1132, ,   , 2012年01月, ,  
41
Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms, Furukawa Kinji, Hattori Mayumi, Ohki Tokimitsu, Kitamura Yoshiaki, Kitade Yukio, Ueno Yoshihito, Bioorganic & Medicinal ChemistryVol.20, No.1, p.16-24, ,   , 2012年01月, ,  
42
Analysis of the molecular interactions and complexation of chloroquine with bovine serum albumin, Kandeel Mahmoud, Kitade Yukio, Drug metabolism and Drug interactionsVol.27, No.1, p.41-46 , ,   , 2011年11月, ,  
43
MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells, Noguchi Syunsuke, Mori Takashi, Hoshino Yuki, Maruo Kohji, Yamada Nami, Kitade Yukio, Naoe Tomoki, Akao Yukihiro, Cancer LettersVol.307, No.2, p.211-220, ,   , 2011年08月, ,  
44
Molecular basis of fosmidomycin’s action on the human malaria parasite Plasmodium falciparum, Umeda Tomonobu, Tanaka Nobutada, Kusakabe Yoshio, Nakanishi Masayuki, Kitade Yukio, Nakamura Kazuo T, Scientific reportsVol.1, No.9, ,   , 2011年06月, ,  
45
Roles of rat and human aldo-keto reductases in metabolism of farnesol and gerantlgeraniol, Endo Satoshi, Matsunaga Toshiyuki, Ohta Chisato, Soda Midori, Kanamori Ayano, Kitade Yukio, Ohno Satoshi, Tajima Kazuo, El-Kabbani Ossama, Hara Akira, Chemico-Biological InteractionsVol.191, No.1-3, p.261-268, ,   , 2011年05月, ,  
46
Binding dynamics and energetic insight into the molecular forces driving Nucleotide binding by guanylate kinase, Kandeel Mahmoud, Kitade Yukio, Journal of Molecular RecognitionVol.24, No.2, p322-332, ,   , 2011年04月, ,  
47
Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction, Shiraishi Takao, Kitamura Yoshiaki, Ueno Yoshihito, Kitade Yukio, Chemical CommunicationsVol.47, No.9, p2691-2693, ,   , 2011年03月, ,  
48
The substrate binding preferences of Plasmodium thymidylate kinase, Kandeel Mahmoud, Kitade Yukio, Biological & pharmaceutical bulletinVol.34, No.1, p.173-176, ,   , 2011年01月, ,  
49
Incorporation of biaryl units into the 5’ and 3’ ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance, Yoshikawa Kayo, Ogata Aya, Matsunaga Chiho, Kohara Michinori, Ida Hideo, Kitade Yukio, Ueno Yoshihito, Bioconjugate ChemistryVol.22, No.1, p.42-49, ,   , 2011年01月, ,  
50
Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model, Takigami Iori, Ohno Takatoshi, Kitade Yukio, Hara Akira, Nagano Akihito, Kawai Gou, Saitou Mitsuru, Matsuhashi Aya, Yamada Kazunari, Shimizu Katsuji, International Journal of CancerVol.128, No.1, p.216-226, ,   , 2011年01月, ,  
51
In vitro assessment of anticryptosporidial efficacy and cytotoxicity of adenosine analogues using a SYBR Green real-time PCR method, Arai Tomoko, Kimata Isao, Kitade Yukio, Nakamoto Kentaro, Tokoro Masaharu, Journal of Antimicrobial ChemotherapyVol.66, No.3, p.560-563, ,   , 2011年01月, ,  
52
Biaryl modification of the 5 '-terminus of one strand of a microRNA duplex induces strand specificity, Ogata Aya, Furukawa Chihiro, Sakurai Kouhei, Iba Hideo, Kitade Yukio, Ueno Yoshihito, Bioorganic & Medicinal Chemistry LettersVol.20, No.24, p.7299-7302, ,   , 2010年12月, ,  
53
Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line, Sato Akira, Naito Tomoharu, Hiramoto Akiko, Goda Kazuto, Omi Takuya, Kitade Yukio, Sasaki Takuma, Matsuda Akira, Fukushima Masakazu, Wataya Yusuke, Kim Hye-Sook, The FEBS JournalVol.277, No.21, p.4464-4473, ,   , 2010年11月, ,  
54
roperties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10), Endo Satoshi, Matsunaga Toshiyuki, Kuragano Tsukasa, Ohno Satoshi, Kitade Yukio, Tajima Kazuo, El-Kabbani Ossama, Hara Akira, Archives of Biochemistry and BiophysicsVol.503, No.2, p.230-237, ,   , 2010年11月, ,  
55
Substrate specificity and nucleotides binding properties of NM23H2/nucleoside diphosphate kinase homolog from Plasmodium falciparum, Kandeel Mahmoud, Kitade Yukio, Journal of Bioenergetics and BiomembranesVol.42, No.5, p.361-369, ,   , 2010年10月, ,  
56
Diazirine-containing RNA photocrosslinking probes for the study of siRNA-protein interactions, Kuboe Satoru, Yoda Mayuko, Ogata Aya, Kitade Yukio, Tomari Yukihide, Ueno Yoshihito, Chemical CommunicationsVol.46, No.39, p7367-7369, ,   , 2010年10月, ,  
57
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10, Endo Satoshi, Matsunaga Toshiyuki, Kuwata Kazuo, Zhao Hai-Tao, El-Kabbani Ossama, Kitade Yukio, Hara Akira, Bioorganic & Medicinal ChemistryVol.18, No,7, p.2485-2490, ,   , 2010年04月, ,  
58
Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum, Umeda Tomonobu, Tanaka Nobutada, Kusakabe Yoshio, Nakanishi Masayuki, Kitade Yukio, Nakamura Kazuo T, Acta Crystallogr Sect F Vol.66, No.3, p.330-332, ,   , 2010年03月, ,  
59
Ligand-Free and Heterogeneous Palladium on Carbon-Catalyzed Hetero-Suzuki-Miyaura Cross-Coupling, Kitamura Yoshiaki, Sako Satoko, Tsutsui Azusa, Monguchi Yasunari, Maegawa Tomohiro, Kitade Yukio, Sajiki Hironae, Advanced Synthesis & CatalysisVol.352, No.4, p.718-730, ,   , 2010年03月, ,  
60
Crystallization of mouse S-adenosyl-L-homocysteine hydlase, Ishihara Masaaki, Kusakabe Yoshio, Ohsumichi Tsuyoshi, Tanaka Nobutada, Nakanishi Masayuki, Kitade Yukio, Nakamura Kazuo T, Acta Crystallogr Sect F Vol.66, No.3, p.313-315, ,   , 2010年03月, ,  
61
Crystallization and preliminary X-ray crystallographic study of phosphoglucose isomerase from Plasmodium falciparum, Aoki Ken-ichi, Tanaka Nobutada, Kusakabe Yoshio, Fukumi Chiharu, Haga Arayo, Nakanishi Masayuki, Kitade Yukio, Kazuto T. Nakamura, Acta Crystallogr Sect F Vol.66, No.3, p.333-336, ,   , 2010年03月, ,  
62
5’-O-Dephosphorylated 2’,5’-oligoadenylate (2-5A) with 8-methyladenosine at the 20-terminus activates human RNase L, Nagaoka Kumi, Kitamura Yoshiaki, Ueno Yoshihito, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.20, No.3, p.1186-1188, ,   , 2010年02月, ,  
63
Role of anti-oncomirs miR-143 and -145 in human colorectal tumors , Akao Yukihiro, Nakagawa Yoshihito, Hirata Ichiro, Iio Akio, Itoh Tomohiro, Kojima Keishi, Nakashima Remi, Kitade Yukio, Naoe Tomoki, Cancer Gene TherapyVol.17, No.6, p.398-408, ,   , 2010年01月, ,  
64
Synthesis and Properties of Oligonucleotides Containing Novel Fluorescent Biaryl Units, Ueno Yoshihito, Komatsuzaki Shinji, Takasu Keiji, Kawai Satoru, Kitamura Yoshiaki, Kitade Yukio, European Journal of Organic ChemistryVol.2009, No.28, p.4763-4769, ,   , 2009年10月, ,  
65
Radical-mediated stannylation of vinyl sulfones: access to novel 4 '-modified neplanocin A analogues, Kumamoto Hiroki, Deguchi Kazuki, Wagata Tadashi, Furuya Yuu, Odanaka Yuki, Kitade Yukio, Tanaka Hiromichi, TetrahedronVol.65, No.38, p.8007-8013, ,   , 2009年09月, ,  
66
Bioinformatics, enzymologic properties and comprehensive tracking of Plasmodium falciparum nucleoside diphosphate kinase, Kandeel Mahmoud, Miyamoto Tatsuya, Kitade Yukio, Biological & pharmaceutical bulletinVol.32, No.8, p.1321-1327, ,   , 2009年08月, ,  
67
Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety, Ueno Yoshihito, Kawamura Akihiro, Takasu Keiji, Komatsuzaki Shinji, Kato Takumi, Kuboe Satoru, Kitamura Yoshiaki, Kitade Yukio, Organic & Biomolecurar ChemistryVol.7, No.13, p.2761-2769, ,   , 2009年08月, ,  
68
Kinetic studies of AKR1B10, human aldose reductase-like protein: Endogenous substrates and inhibition by steroids, Endo Satoshi, Matsunaga Toshiyuki, Mamiya Hiroaki, Ohta Chisato, Soda Midori, Kitade Yukio, Tajima Kazuo, Zhao Hai-Tao, El-Kabbani Ossama, Hara Akira, Archives of Biochemistry and BiophysicsVol.487, No.1, p.1-9, ,   , 2009年07月, ,  
69
Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, Naito Tomoharu, Yokogawa Tatsushi, Takatori Satoshi, Goda Kazato, Hiramoto Akiko, Sato Akira, Kitade Yukio, Sasaki Takuma, Matsuda Akira, Fukushima Masakazu, Wataya Yusuke, Kim Hye-Sook, Cancer Chemotherapy and PharmacologyVol.63, No.5, p.837-850, ,   , 2009年04月, ,  
70
Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress, Endo Satoshi, Matsunaga Toshiyuki, Mamiya Hiroaki, Hara Akira, Kitade Yukio, Tajima Kazuo, El-Kabbani Ossama, Chemico-Biological InteractionsVol.178, No.1-3, p.151-157, ,   , 2009年03月, ,  
71
Synthesis of nuclease-resistant siRNAs possessing universal overhangs, Ueno Yoshihito, Watanabe Yuuji, Shibata Aya, Yoshikawa Kayo, Takano Takashi, Kohara Michinori, Kitade Yukio, Bioorganic & Medicinal ChemistryVol.17, No.5, p.1974-1981, ,   , 2009年03月, ,  
72
Effect of incorporation of alkyl linkers into siRNAs on RNA interference, Ueno Yoshihito, Yoshikawa Kayo, Kitamura Yoshiaki, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.19, No.3, p.875-877, ,   , 2009年02月, ,  
73
Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for development of a new drug target, Kandeel Mahmoud, Ando Takayuki, Kitamura Yoshiaki, Abdel-Aziz, M, Kitade Yukio, ParasitologyVol.136, No.1, p.11-25, ,   , 2009年01月, ,  
74
Copper/HP20: novel and polymer-supported copper catalyst for Huisgen cycloaddition, Kitamura Yoshiaki, Taniguchi Kazumi, Maegawa Tomohiro, Monguchi Yasunari, Kitade Yukio, Sajiki Hironao, HeterocyclesVol.77, No.1, p.521-532, ,   , 2009年01月, ,  
75
Synthesis and properties of siRNAs 5′-amino-2′,5′-dideoxy-2′α-fluororibonucleosides, Ueno Yoshihito, Hirai Miki, Yoshikawa Kayo, Kitamura Yoshiaki, Hirata Yoko, Kiuchi Kazutoshi, Kitade Yukio, TetrahedronVol.64, No.49, p.11328-11334, ,   , 2008年12月, ,  
76
Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase, Endo Satoshi, Matsunaga Toshiyuki, Kitade Yukio, Ohno Satoshi, Tajima Kazuyo, El-Kabbani Ossama, Hara Akira, Biochemical and Biophysical Research CommunicationsVol.377, No.4, p.1326-1330, ,   , 2008年12月, ,  
77
Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate backbones in their 3′-overhang regions, Ueno Yoshihito, Inoue Takumi, Yoshida Mahito, Yoshikawa Kayo, Shibata Aya, Kitamura Yoshiaki, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.18, No.19, p.5194-5196, ,   , 2008年10月, ,  
78
Synthesis of carbocyclic 2-subsituted adenine nucleoside and related analogs, Zulfiqar Fazila, Kojima Hiroharu, Nakanishi Masayuki, Ando Takayuki, Kitade Yukio, Nucleosides, Nucleotides and Nucleic AcidsVol.27, No.10-11, p.1153-1157, ,   , 2008年09月, ,  
79
Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3′-termini, Ueno Yoshihito, Kawada Koshi, Naito Tomoharu, Shibata Aya, Yoshikawa Kayo, Kim Hye-Sook, Wataya Yusuke, Kitade Yukio, Bioorganic & Medicinal ChemistryVol.16, No.16, p.7698-7704, ,   , 2008年08月, ,  
80
Inhibition of human immunodeficiency virus type 1 replication by blocking I kappa B kinase with noraristeromycin, Asamitsu Kaori, Yamaguchi Tsuyoshi, Nakata Kenji, Hibi Yurina, Victoriano Ann-Florence B, Imai Kenichi, Onozaki Kikuo, Kitade Yukio, Okamoto Takashi, The Journal of BiochemistryVol.144, No.5, p.581-589, ,   , 2008年08月, ,  
81
Synthesis of 3´,4´-epoxynor- aristeromycin analogs for molecular labeling probe of S-adenosyl-L-homocysteine hydrolase, Kojima Hiroharu, Kozaki Atsushi, Iwata Masafumi, Ando Takayuki, Kitade Yukio, Bioorganic & Medicinal ChemistryVol.16, No.13, p.6575-6579, ,   , 2008年07月, ,  
82
Molecular cloning, expression, characterization and mutation of Plasmodium falciparum guanylate kinase, Kandeel Mahmoud, Nakanishi Masayuki, Ando Takayuki, Shazly Kamal-El, Yosef Tarek, Ueno Yoshihito, Kitade Yukio, Molecular and Biochemical ParasitologyVol.159, No.2, p.130-133, ,   , 2008年06月, ,  
83
Molecular characterization, heterologous expression and kinetic analysis of recombinant Plasmodium falciparum thymidylate kinase, Kandeel Mahmoud, Kitade Yukio, The Journal of Biological ChemistryVol.144, No.2, p.245-250, ,   , 2008年05月, ,  
84
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase, Ando Takayuki, Iwata Masafumi, Zulfiqar Fazila, Miyamoto Tatsuya, Nakanishi Masayuki, Kitade Yukio, Bioorganic & Medicinal ChemistryVol.16, No.7, p.3809-3815, ,   , 2008年04月, ,  
85
Synthesis of 4¢-modified noraristeromycins to clarify the effect of the 4¢-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase, Ando Takayuki, Kojima Kenji, Chahota Praveen, Kozaki Atsushi, Milind Nikalje-D, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.18, No.8, p.2615-2618, ,   , 2008年04月, ,  
86
Expansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesis, Ito Kosuke, Nakanishi Masayuki, Lee Woo-Cheol, Zhi Yuehua, Sasaki Hiroshi, Zenno Shuhei, Saigo Kaoru, Kitade Yukio, Tanokura Masaru, The Journal of Biological ChemistryVol.283, No.20, p.13889-13896, ,   , 2008年03月, ,  
87
Synthesis of novel 4’-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-homocysteine hydrolase, Kumamoto Hiroki, Deguchi Kazuki, Takahashi Nonoko, Tanaka Hiromichi, Kitade Yukio, Nucleosides, Nucleotides & Nucleic AcidsVol.26, No.6-7, p.733-736, ,   , 2007年12月, ,  
88
Facile synthesis of 1',2'-cis-β-pyranosyladenine nucleosides, Ando Takayuki, Shinohara Hisashi, Luo Xiong, Kandeel Mahmoud, Kitade Yukio, Carbohydrate ResearchVol.342, No.17, p.2641-2648, ,   , 2007年12月, ,  
89
Depolarization-Induced Differentiation of PC12 Cells is Mediated by Phospholipase D2 through the Transcription Factor CREB Pathway, Banno Yoshiko, Nemoto Satoshi, Murakami Masashi, Kimura Masashi, Ueno Yoshihito, Ohguchi Kenji, Hara Akira, Okano Yukio, Kitade Yukio, Onozuka Minoru, Murate Takashi, Nozawa Yoshinori, Journal of NeurochemistryVol.104, No.5, p.1372-1386, ,   , 2007年11月, ,  
90
M., Biologically stable 2-5A analogs containing 3'-O,4'-C-bridged adenosine as potent RNase L agonists, Morita Koji, Kaneko Masakatsu, Obika Satoshi, Imanishi Takeshi, Kitade Yukio, Makoto Koizumi, Chem Med ChemVol.2, No.12, p.1703-1707, ,   , 2007年10月, ,  
91
Down-regulation of microRNAs-143 and -145 in B-cell malignancies, Akao Yukihiro, Nakagawa Yoshihito, Kitade Yukio, Kinoshita Tomohiro, Naoe Tomoki, Cancer ScienceVol.98, No.12, p.1914-1920, ,   , 2007年09月, ,  
92
RNAi knockdown of caspase-activated DNase inhibits rotenone-induced DNA fragmentation in HeLa cells, TsurutaTadamiki, Oh-hashi Kentaro, Ueno Yoshihito, Kitade Yukio, Kiuch Kazutoshi, Hirata Yoko, Neurochemistry InternationalVol.50, No.4, p.601-606, ,   , 2007年03月, ,  
93
4-Fluorinated carbocyclic nucleosides: synthesis and inhibitory acticity against S-ademosyl-L-homocysteine hydrolase, Kitade Yukio, Ando Takayuki, Yamaguchi Tsuyoshi, Hori Ayumi, Nakanishi Masayuki, Ueno Yoshihito, Bioorganic & Medicinal Chemistry LettersVol.14, No.16, p.5578–5583, ,   , 2006年08月, ,  
94
Three-Dimensional Structure of AzoR (azoreductase) from Escherichia coli; AN OXIDEREDUCTASE CONSERVED IN MICROORGANISMS, Ito Kosuke, Nakanishi Masayuki, Lee Woo-Cheol, Sasaki Hiroshi, Zenno Shuhei, Saigo Kaoru, Kitade Yukio, Tanokura Masaru, The Journal of Biological ChemistryVol.281, No.25, p.20567-20576, ,   , 2006年07月, ,  
95
Synthesis of Linked Triple Helical DNAs Possessing High Affinity to Triple Helical DNA Binding Protein, Shibata Aya, Ueno Yoshihito, Shinbo Koichiro, Nakanishi Masayuki, Matsuda Akira, Kitade Yukio, Bioorganic & Medicinal Chemistry LettersVol.16, No.5, p.1410–1413, ,   , 2006年03月, ,  
96
Synthesis and hydridization properties of oligonucleotides containing (2S,3R)-9-(2,3,4-trihydroxybutyl)adenine, Ueno Yoshihito, Ishihara Shinji, Ito Yasutomo, Kitade Yukio, Nucleosides, Nucleotides & Nucleic AcidsVol.25, No.4-6, p.475-487, ,   , 2006年01月, ,  

 

講演・口頭発表等
No.タイトル, 講演者, 会議名, 開催地, 開催年月日, 主催者 
1
RNA修飾のためのマルチバレントなN-アセチルグルコサミンアナログの合成, 高橋哲也、柴田綾、…他2名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
2
RNA修飾のためのグルコサミンダイマーの合成, 傍島孝明、柴田綾、…他3名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
3
グルコサミン結合型RNA分子の生物学的評価, 柴田綾、溝口真帆代、…他2名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
4
ピリミジン塩基誘導体の新規環拡大反応, 長屋優貴、大口明日基、…他2名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
5
ドッキングスタディを用いたPAZドメイン高親和性分子の探索と機能性評価, 近藤和仁、Mahmoud KANDEEL、喜多村徳昭、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
6
強力RNaseL活性化能を有する抗癌剤ハイブリッド型2-5A誘導体の開発, 喜多村徳昭、鬼頭誠弥、…他3名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
7
ヒトArgonaute2 PAZ高親和性分子の探索とRNA干渉への応用, 近藤智哉、田中章裕、…他2名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
8
抗マラリア薬開発を指向した熱帯熱マラリア原虫Ap4A hydrolase阻害剤の探索, 大橋雄介、Waleed OSMAN、…他2名、北出幸夫, 日本薬学会第136年会, , 2016年03月,  
9
Chemical modification of the 3'-dangling end of dsRNAs for the development of RNA medicines, Yukio Kitade, The International Chemical Congress Of Pacific Basin Societies 2015, , 2015年12月,  
10
RNA医薬を指向する化学修飾RNA分子の開発とその生物機能, 北出幸夫、柴田綾、喜多村徳昭、赤尾幸博, 日本核酸医薬学会第1回年会(旧アンチセンスシンポジウム), , 2015年11月,  
11
自己切断型遺伝子検出プローブの開発, 楯裕基、柴田綾、北出幸夫, 日本核酸医薬学会第1回年会(旧アンチセンスシンポジウム), , 2015年11月,  
12
Reduction-responsive thrombin-binding DNA aptamer, Masahiro Kamimura, Masato Ikeda, Yukio Kitade, 第42回国際核酸化学シンポジウム, , 2015年09月,  
13
Artificial micro RNA-205 modified at the 3'-dangling end inhibits the growth of canine melanoma, Yukio Kitade, Takashi Mori, Shunsuke Noguchi, Yukihiro Akao, 10th Annual Meeting of the Oligonucleotide Therapeutics Society, , 2014年09月,  
14
Synthesis of ologonucleotides possesing ethynylbenzene glycol and their application for PET-labeling, Yukio Kitade, Qin Ren, Yoshiaki Kitamura, Remi Nakashima, aya Shibata, Masato Ikeda, International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, , 2014年08月,  
15
Synthesis of ologonucleotides possesing ethynylbenzene-substituted glycol and their properties, Qin Ren, Yoshiaki Kitamura, Remi Nakashima, Aya Shibada, Masato Ikeda, Yukio Kitade, Drug Discovery Chemistry, , 2014年,  
16
Chemically modified microRNA-205 possessing benzene-pyridine analogs at the 3'-dangling end inhibits the growth of melanoma cells, Yukio Kitade, Shunsuke Noguchi, Takashi Mori, Yukihiro Akao, microRNA as Biomarkers and Diagnostics conference, , 2014年,  
17
Synthesis of the chemically modified miRNAs and their anticancer activities, Yukio Kitade, microRNA Europe, , 2013年,  

 

外部資金導入
No.タイトル, 提供機関, 制度名, 研究期間, 代表者 
1
次世代型医療を実現する実用的RNA分子の開発, 科学技術振興機構, ,  2015年 - 現在,  
2
ポスト修飾用DDSプラットフォームの開発とDDSハイブリッド型RNA医薬の創製, 塩野義製薬㈱, ,  2014年 - 現在,  
3
RNA創薬を目指した新規RNA含有ナノフィルム製剤の開発, 岐阜県研究開発財団, ,  2013年 - 現在,  
4
RNA創薬を目指す実用的RNA分子の創製と核酸オリゴマーのPETプローブ化, 学術振興会, ,  2012年 - 2014年,  
5
標的外遺伝子への影響(オフ・ターゲット効果)を回避する実用的なRNA分子の開発, 科学技術振興機構, ,  2011年 - 2012年,  
6
核酸・ペプチド・糖のケミカルバイオロジーを基盤とした創薬分子イメージング, 文部科学省, ,  2007年 - 2009年,  
7
マイクロRNAを用いた制がん戦略:大腸がんにおけるmicroRNA-143と145の発癌への関与と治療への応用, 科学技術振興機構, ,  2007年 - 2008年,  
8
RNA創薬を目指す高機能性核酸オリゴマーのPETプローブ化法の開発, 科学技術振興機構, ,  2007年 - 現在,  
9
がん治療を指向する高機能性マイクロRNAの開発, 学術振興会, ,  2006年 - 2007年,  
10
高効率ノックダウン機能を有するsiRNA製造法の開発と活用, 経済産業省, ,  2005年 - 2006年,  

 

連携可能な研究テーマ
No.タイトル, 年月 
1
マイクロカロリメータ (ITC) を用いた生体反応解析,  2016年04月01日 - 現在 
2
核酸医薬の開発,  2016年04月01日 - 現在 
3
抗体など医薬品のPETラベル化,  2016年04月01日 - 現在 
4
生体分子の高機能化,  2016年04月01日 - 現在 
5
ドラッグデリバリーシステム (DDS) の開発,  2016年04月01日 - 現在